WebHere we show that HSC aging critically depends on bone marrow innervation by the sympathetic nervous system (SNS), as loss of SNS nerves or adrenoreceptor β3 signaling in the bone marrow microenvironment of young mice led to premature HSC aging, as evidenced by appearance of HSC phenotypes reminiscent of physiological aging. Web2 days ago · Guillermo del Toro's Pinocchio (OST) Thou art gone, thy life hast fled. All shall now bewail the dead. No more flesh and no more bone. No more trouble to bemoan. Like a wave along the shore. You have passed, you will complain nevermore. The late, late lamented. For death can’t be prevented.
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