Carboxymethylproline
Web(2S,5S)-5-Carboxymethylproline C7H11NO4 CID 447989 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … WebCarboxymethylproline synthases (e.g. CarB and ThnE from Pectobacterium carotovorum and Streptomyces cattleya, respectively) catalyse the formation of carboxymethylproline intermediates in the biosynthesis of the clinically important carbapenem subfamily of β-lactam antibiotics.
Carboxymethylproline
Did you know?
WebStereoselective C C bond formation catalysed by engineered carboxymethylproline synthases. Christopher Schofield Refaat Hamed. 2011, Nature Chemistry. The user has requested enhancement of the downloaded file. All in-text references underlined in blue are added to the original document and are linked to publications on ResearchGate, letting … WebCarboxymethylproline synthase (CarB) catalyzes the committed step in the biosynthesis of (R)-1-carbapen-2-em-3-carboxylate, the simplest member of the carbapenem family of β …
WebRole of carboxymethylproline synthases in carbapenem biosynthesis and CarB engineering. (A) Biosynthesis of the simplest carbapenem as catalyzed by the crotonase … WebJul 7, 2005 · carboxymethylproline synthase (CarB) from pectobacterium carotovora, complexed with acetyl CoA and bicine. PDB DOI: 10.2210/pdb2A81/pdb; Classification: …
WebMay 1, 2011 · We describe protein engineering studies on 5-carboxymethylproline synthases, members of the crotonase superfamily, aimed at enabling stereoselective C-C bond formation leading to N-heterocycles... WebApr 3, 2011 · Carboxymethylproline synthases (CMPSs, such as CarB from Pectobacterium carotovorum and ThnE from Streptomyces cattleya) are crotonase …
WebMar 7, 2010 · Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. The utility of wild-type and variant carboxymethylproline synthases for …
WebEnzyme in action: Labeling studies and the finding that carboxymethylproline synthase catalyzes production of deuterated (2S,5S)-6,6′-dimethyl-trans-carboxymethylproline (3) from dimethylmalonyl-CoA (1) and labeled l-pyrroline-5-carboxylate (2) limit possible mechanisms of C C bond formation and thioester hydrolysis. horizontal bop meaningWebUnusual antibiotic biosynthesis enzymes: The observation that formation of trans-carboxymethylproline (t-CMP) and 6-methyl-t-CMP is catalyzed by ThnE from … lori tries dirty herb on for sizeWebCarB catalyzes formation of (2 S ,5 S )-carboxymethylproline [ (2 S ,5 S )- t -CMP] from malonyl-CoA and l -glutamate semialdehyde. In addition to using a cosubstrate, CarB … lori trevors winnipegWebNov 7, 2024 · Carbapenems are biologically mainly active in the infections like urinary tract infections, bloodstream infections, tuberculosis, intra-abdominal infections, and pathogens like anaerobes, gram-positive and gram-negative bacteria. Keywords: Carbapenem, antibiotics, structure, chemistry, resistance, mechanism of action. « Previous Next » lori trentham tahlequah okWebThe utility of wild-type and variant carboxymethylproline synthases for biocatalysis was demonstrated by preparing functionalised 5-, 6- and 7-membered N -heterocycles from amino acid aldehydes and (alkylated) malonyl-coenzyme A derivatives; the N -heterocycles produced were converted to the corresponding bicyclic β-lactams by a carbapenem … horizontal boring attachment for excavatorWebApr 1, 2005 · Carboxymethylproline synthase was shown to condense L-glutamate semialdehyde with malonyl-coenzyme A to produce (2S,5S)-carboxymethylproline, while incubation of D-glutamate semialdehyde... lori trumbo ratemyprofessorWebMar 1, 2004 · Carboxymethylproline synthase (CarB) catalyzes the committed step in the biosynthesis of (R)-1-carbapen-2-em-3-carboxylate, the simplest member of the carbapenem family of beta-lactam... loritta 5 pairs womens wool socks