WebMar 21, 2024 · PLIN2 (Perilipin 2) is a Protein Coding gene. Diseases associated with PLIN2 include Sebaceous Adenocarcinoma and Chanarin-Dorfman Syndrome . Among its related pathways are Selective … WebExam Information. To become certified as a CST (Certified Service Technician®), you …
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WebNov 23, 2024 · Importantly, we found that the percentage of Plin2 + microglia was much higher in apoE4 mice (26%) compared to apoE2 (9%) and apoE3 (13%) mice (Fig. 6D). We next validated genes associated with lipid transport and metabolism and showed that Lpl and Apoc1 were altered in an apoE isoform-dependent manner. WebAug 23, 2024 · The lack of foamy microglia in TREM2 KO was confirmed by immunohistochemistry (IHC) using antibodies against perilipin 2 (PLIN2), a structural component of lipid droplets, and IBA1. In line with our ultrastructural analysis, the number of IBA1 + PLIN2 + cells increased in WT lesions at 21 and 62 dpi but not in TREM2 KO …
WebAug 28, 2024 · Lipid droplets (LDs) are lipid storage organelles that consist of a central core of neutral lipids surrounded by a phospholipid monolayer decorated with a unique set of integral and peripheral proteins. Invariably, at least one member of the perilipin family of proteins (PLIN1-5) associates with LDs in all cell types. Despite key roles of PLIN2 in … WebSep 13, 2024 · Myelin uptake increases PLIN2 expression in macrophages in a PPARγ-dependent manner. Demyelinating lesions are characterized by the abundant presence of foamy macrophages loaded with cholesterol-containing LDs [].As PLIN2 is the main LD-associated protein on cholesterol-containing LDs and given its key role in LD biology [], …
Polyclonal Antibody for studying perilipin 2. Validated for Western Blotting, Immunoprecipitation. Highly specific and rigorously validated in-house, Perilipin-2 Antibody (CST #45535) is ready to ship. WebPLIN2 is an inherent perilipin protein, and its expression and phosphorylation are involved in lipolysis, lipophagy, lipid droplet fusion, and signal transduction. 49–52 PLIN2 activation-mediated LDs accumulation was observed in microglia activated by various inflammatory stimuli, which was closely related to the production of ROS and ...
WebFeb 15, 2016 · Abstract. Perilipin2 (Plin2), also known as adipose differentiation-related …
WebSep 9, 2024 · A recent study showed that the generation of ROS can increase perilipin 2 (Plin2) expression in HepG2 cells. Some evidence has also demonstrated the association between Plin2 expression and renal tumors. However, the underlying mechanism of Plin2 in I/R-induced acute kidney injury (AKI) remains elusive. Here, using a mouse model of I/R … fish guts meaningWebApr 28, 2024 · Moreover, PLIN2 knockout mice are resistant to diet-induced obesity, fatty liver disease and alcohol-induced steatosis, suggesting that PLIN2 is responsible for lipid accumulation, particularly in the liver [41, 42]. Taken together, these studies suggest that PLIN2 promotes LD formation and thereby protects TG from lipolysis. fish guts in wineWebAug 1, 2012 · The plin2-EYFP or plin1ΔC-EYFP fragment was shuttled into the transformation vector pUAST-attB through EcoRI and XbaI sites. All constructs requiring PCR amplification were confirmed by sequencing. All quantitative RT-PCRs were performed on an ABI PRISM 7900HT real-time cycler (Applied Biosystems) using Power SYBR … fish guts as glueWebMar 29, 2024 · Upregulated monocyte expression of PLIN2 is associated with early arterial injury in children with overweight/obesity. Pisano E, et al. Atherosclerosis, 2024 Jun. PMID 34044206. Correlation of perilipin 2 and lipid metabolism in elective cesarean section and vaginal delivery: a prospective study with oxidative and apoptotic pathways. can a sprint phone work on cricketWebJun 16, 2024 · plin2 Background Perilipin-2/Plin-2, also known as adipose differentiation-related protein (ADFP), ADRP, and adipophilin, is a … can a sprint phone work on attWebPerilipin-2/Plin-2, also known as adipose differentiation-related protein (ADFP), ADRP, and adipophilin, is a member of the perilipin family of lipid droplet (LD) proteins that functions in lipid accumulation, lipid storage, … can a sprint phone be unlockedWebDec 13, 2024 · For example, PLIN2 and PLIN3 expression predominates in mouse liver, muscle cells , and pancreatic islets , whereas PLIN1 is significantly upregulated as preadipocytes mature into adipocytes . Perilipin protein function has been studied primarily in rodents, and, for example, PLIN2 ( 17 , 18 ) or PLIN3 ( 19 ) null mice are protected … fish guts san diego