Phosphopantetheine adenylyltransferase
WebIn enzymology, a pantetheine-phosphate adenylyltransferase ( EC 2.7.7.3) is an enzyme that catalyzes the chemical reaction. ATP + 4'-Phosphopantetheine diphosphate + 3' … WebMar 24, 2010 · To identify the phosphopantetheine adenylyltransferase sub-site bound by these inhibitors, two techniques were utilized: steady-state enzyme kinetics and a novel 19 F NMR method in which fluorine-containing fragments that bind the ATP and/or phosphopantetheine sites serve as competitive reporter probes. These data are …
Phosphopantetheine adenylyltransferase
Did you know?
WebApr 4, 1999 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria that catalyses a rate-limiting step in coenzyme A (CoA) biosynthesis, by … WebSep 1, 1999 · Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in coenzyme A (CoA) biosynthesis: the reversible adenylation of 4'-phosphopantetheine yielding 3'-dephospho-CoA and pyrophosphate. Wild-type PPAT from Escherichia coli was purified to homogeneity.
WebFeb 7, 2024 · Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis in complex with 3-(1H-indol-3-yl)propanoic acid at 1.6A resolution. WebInhibitors of 4′-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed...
WebApr 4, 1999 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria that catalyses a rate-limiting step in coenzyme A (CoA) biosynthesis, by transferring an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA). WebPhosphopantetheine Adenylyltransferase (PPAT) is an enzyme that catalyzes the penultimate step in the biosynthesis of Coenzyme A (CoA), which is the active and …
WebFeb 1, 2024 · Phosphopantetheine Adenylyltransferase (PPAT) is an enzyme that catalyzes the penultimate step in the biosynthesis of Coenzyme A (CoA), which is the active and physiologically functional form of ...
WebINIS Repository Search provides online access to one of the world's largest collections on the peaceful uses of nuclear science and technology. The International Nuclear Information System is operated by the IAEA in collaboration with over 150 members. fit life southington ctWebPhosphopantetheine adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosynthetic pathway. PPAT catalyzes the reversible transfer of an adenylyl group from Mg2+:ATP to 4′-phosphopantetheine to form 3′-dephospho-CoA (dPCoA) and pyrophosphate. can human interaction aid with depressionWebApr 15, 1999 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria that catalyses a rate-limiting step in coenzyme A (CoA) biosynthesis, by transferring an adenylyl group from ATP to 4′-phosphopantetheine, yielding dephospho-CoA (dPCoA). Each phosphopantetheine adenylyltransferase (PPAT) subunit displays a dinucleotide … fit life supportWebMay 30, 2024 · In this study, phosphopantetheine adenylyltransferase (PPAT/CoaD) enzyme, involved in the coenzyme A biosynthesis pathway, was evaluated in the context of fragment-based discovery of new inhibitors targeting Mycobacterium abscessus. The structures of PPAT from M. abscessusMab PPAT, facilitating the initiation of a structure … can human insulin be used for catsWebFeb 1, 2024 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria that catalyzes the rate-limiting step in coenzyme A (CoA) biosynthesis by … fit lifestylesWebFeb 9, 2024 · Generally, CoA is synthesised from pantothenate (vitamin B 5) in five steps. 7 Phosphopantetheine adenylyltransferase (PPAT), a hexameric protein encoded by the coaD gene, catalyses the penultimate step—the transfer of an adenylyl group from ATP to 4′-phosphopantetheine, to form dephospho-CoA and pyrophosphate. fitlife summertownWebInhibitors of 4′-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed inhibition of PPAT isozymes from several species, with the most potent inhibition of enzymes from Gram-positive species. Mode-of-inhibition studies with … can humanity overcome its violent tendencies